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KMID : 0861019990140010141
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Korea Journal of Herbology
1999 Volume.14 No. 1 p.141 ~ p.147
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Anti - Hypetensive Effects of Expelling Pathogenic Wind - Heat Drugs
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金護哲/Kim, Ho-Cheol
朴珠瑛/安德均/Park, Ju-Young/Ahn, Duk-Kyun
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Abstract
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Balsanpungyeolyak, Expelling Pathogenic Wind-Heat Drug, have been used to treat the symptoms such as fever, headache, neck stiffness and skin disturbance which are commonly shown in systemic fever disease like influenza. We thought that the symptoms from the actions of wind and heat in Traditional Korean Medicine are similar to the ones of hypertensive patients in clinic. We chose five drugs among expelling pathogenic wind-heat drugs, Puerariae Radix, Chrysanthemi Flos, Menthae Herba, Mori Folium, and Arctii Fructus, to investigate their antihypertensive effects on S.H.R. and normotensive S.D rats, direct relaxant activity on isolated rabbit aorta, and ACE inhibitory activity. Menthae Herba and Arctii Fructus decreased blood pressure significantly in SHR, but not in normotensive rats, Direct vasodilatative effects on isolated rabbit aorta was not observed in any group. Chrysanthemi Flos, Menthae Herba, Mori Folium, and Arctii Fructus inhibited the actions of ACE dose-dependently. Therefore it is concluded that expelling pathogenic wind-heat drugs has not direct correlation with antihypertensive activity. However, it can be suspected that some drugs for dispersing the actions of wind and heat may regulate blood pressure through ACE inhibition and further study will be helpful to understand the mechanism.
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